lithium perchlorate mediated amination reaction of aldehydes: a novel method for synthesis of n, n-dialkyl-p-silylated amines*

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چکیده

p-silylated n,n-dialkyl amines (5) were easily synthesized in good to excellent yield from aldehydes (1), trimethylsilyldialkylamines (2), and trimethylsilylmethylmagnesium chloride (4) in the presence of 5 m lithium perchlorate solution in diethyl ether. the reaction of (2) with aldehyde proceeded smoothly in the lici0 , to give the imimum salt (3). addition of trimethylsilylmethylrnagnesium chloride (4) gave the desired product

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LITHIUM PERCHLORATE MEDIATED AMINATION REACTION OF ALDEHYDES: A NOVEL METHOD FOR SYNTHESIS OF N, N-DIALKYL-p-SILYLATED AMINES*

P-Silylated N,N-dialkyl amines (5) were easily synthesized in good to excellent yield from aldehydes (1), trimethylsilyldialkylamines (2), and trimethylsilylmethylmagnesium chloride (4) in the presence of 5 M lithium perchlorate solution in diethyl ether. The reaction Of (2) with aldehyde proceeded smoothly in the LiCI0 , to give the imimum salt (3). Addition of trimethylsilylmethylrnagnes...

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part a: application of n-(p-toluenesulfonyl) imidazole (tsim) and triphenylphosphine/carbon tetrachloride in several organic transformations part b: application of 8-bromocaffeine for synthesis of some novel 8-caffeinyl derivatives

بخش اول این پایان نامه به طور عمده بر توسعه کاربردهای جدید n-(پارا-تولوئن سولفونیل) ایمیدازول (tsim) و تری فنیل فسفین/ تتراکلرید کربن در تبدیل گروههای عاملی به یکدیگر استوار است. نظر به تنوع زیاد، دردسترس بودن، سمیت کمتر و نقل و انتقال آسان تر الکل ها نسبت به آلکیل هالیدها، تبدیل مستقیم گروه هیدروکسیل به گروه های عاملی دیگر مثل آزید، نیتریل و استر یکی از مهم ترین تبدیلات در سنتزهای آلی است. با ...

15 صفحه اول

Protecting-group-free synthesis of amines: synthesis of primary amines from aldehydes via reductive amination.

New methodology for the protecting-group-free synthesis of primary amines is presented. By optimizing the metal hydride/ammonia mediated reductive amination of aldehydes and hemiacetals, primary amines were selectively prepared with no or minimal formation of the usual secondary and tertiary amine byproduct. The methodology was performed on a range of functionalized aldehyde substrates, includi...

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-Solid Lithium Perchlorate, a Highly Efficient and Chemoselective Catalyst for the Acetalyzation of Aldehydes

-A simple, efficient, and general method has been developed for the chemoselective acetalization of aldehydes with 1,3-propanediol, 1,2-ethanediol and trimethyl orthoformate in the presence of solid lithium perchlorate under solvent-free conditions. Both cyclic and acyclic acetals of aldehydes were obtained under environmentally benign conditions in good to excellent yields.

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-solid lithium perchlorate, a highly efficient and chemoselective catalyst for the acetalyzation of aldehydes

-a simple, efficient, and general method has been developed for the chemoselective acetalization of aldehydes with 1,3-propanediol, 1,2-ethanediol and trimethyl orthoformate in the presence of solid lithium perchlorate under solvent-free conditions. both cyclic and acyclic acetals of aldehydes were obtained under environmentally benign conditions in good to excellent yields.

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عنوان ژورنال:
journal of sciences islamic republic of iran

جلد ۶، شماره ۳، صفحات ۰-۰

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